Publications

Rare populations of invasive cells drive progression of heterogeneous tumors PDF
_{Leggett SE,# Brennan MC,# Martinez S,Tien J, Nelson CM. Relatively Rare Populations of Invasive Cells Drive Progression of Heterogeneous Tumors. Cel. Mol. Bioeng. (2024).}

3D Traction Force Microscopy in Biological Gels: From Single Cells to Multicellular Spheroids PDF
_{Cheung BCH, Abbed RJ, Wu M,* Leggett SE* Annu. Rev. Biomed, Eng. (2024).}

Mechanobiology of Collective Cell Migration in 3D Microenvironments
_{Hruska AM, Yang H, Leggett SE, Guo M, Wong IY. (2023) Mechanobiology of Collective Cell Migration in 3D Microenvironments. In: Wong, I.Y., Dawson, M.R. (eds) Engineering and Physical Approaches to Cancer. Current Cancer Research. Springer, Cham.}

Tissue Architecture in Cancer Initiation and Progression
_{Leggett, SE, Nelson, CM (2022). Tissue Architecture in Cancer Initiation and Progression. In: Akslen, L.A., Watnick, R.S. (eds) Biomarkers of the Tumor Microenvironment. Springer, Cham.}

The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems
_{Leggett SE, Hruska AM, Guo M, Wong IY. Cell Commun Signal. 2021;19(1):32.}

Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.
_{Leggett SE, Patel M, Valentin TM, Gamboa L, Khoo AS, Williams EK, Franck C, Wong IY. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5655-5663.}

Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development
_{So, E. Y., Sun, C., Wu, K. Q., Driesman, A., Leggett, S., Isaac, M., Spangler, T., Dubielecka-Szczerba, P. M., Reginato, A. M., & Liang, O. D. (2020). Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development. Journal of cellular physiology, 235(2), 1425–1437.}

Motility-limited aggregation of mammary epithelial cells into fractal-like clusters.
_{Leggett SE, Neronha ZJ, Bhaskar D, Sim JY, Perdikari TM, Wong IY. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17298-17306}

Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels
_{Khoo AS, Valentin TM, Leggett SE, et al. Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk-Collagen Hydrogels. ACS Biomater Sci Eng. 2019;5(9):4341-4354. doi:10.1021/acsbiomaterials.9b00519}

Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields
_{Patel M, Leggett SE, Landauer AK, Wong IY, Franck C. Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields. Sci Rep. 2018 Apr 3;8(1):5581.}

Multicellular Tumor Invasion and Plasticity in Biomimetic Materials
_{Leggett SE, Khoo AS, Wong IY. Multicellular tumor invasion and plasticity in biomimetic materials. Biomater Sci. 2017 Jul 25;5(8):1460-1479.}

Stereolithographic Printing of Ionically-Crosslinked Alginate Hydrogels for Degradable Biomaterials and Microfluidics
_{Valentin TM, Leggett SE, Chen PY, et al. Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics. Lab Chip. 2017;17(20):3474-3488. doi:10.1039/c7lc00694b}

Morphological single cell profiling of the epithelial-mesenchymal transition.
_{Leggett SE, Sim JY, Rubins JE, Neronha ZJ, Williams EK, Wong IY. Integr Biol (Camb). 2016 Nov 7;8(11):1133-1144.}

Wrinkled, wavelength-tunable graphene-based surface topographies for directing cell alignment and morphology.
_{Z Wang,# D Tonderys,# SE Leggett,# Williams EK, Kiani MT, Steinberg RS, Qiu Y, Wong IY, Hurt RH. Carbon N Y. 2016 Feb 1;97:14-24. #These authors contributed equally.}

Clustering and jamming in epithelial-mesenchymal co-cultures.
_{Gamboa Castro M, Leggett SE, Wong IY. Soft Matter. 2016 Oct 12;12(40):8327-8337.}

Induction of a Mesenchymal Expression Program in Lung Epithelial Cells by Wingless Protein (Wnt)/β-Catenin Requires the Presence of c-Jun N-Terminal Kinase–1 (JNK1).
_{van der Velden JL, Guala AS, Leggett SE, Sluimer J, Badura EC, Janssen-Heininger YM. Am J Respir Cell Mol Biol. 2012 Sep;47(3):306-14.}