Publications



Rare populations of invasive cells drive progression of heterogeneous tumors PDF
Leggett SE,# Brennan MC,# Martinez S,Tien J, Nelson CM. Relatively Rare Populations of Invasive Cells Drive Progression of Heterogeneous Tumors. Cel. Mol. Bioeng. (2024).





3D Traction Force Microscopy in Biological Gels: From Single Cells to Multicellular Spheroids PDF
Cheung BCH, Abbed RJ, Wu M,* Leggett SE* Annu. Rev. Biomed, Eng. (2024).



Mechanobiology of Collective Cell Migration in 3D Microenvironments
Hruska AM, Yang H, Leggett SE, Guo M, Wong IY. (2023) Mechanobiology of Collective Cell Migration in 3D Microenvironments. In: Wong, I.Y., Dawson, M.R. (eds) Engineering and Physical Approaches to Cancer. Current Cancer Research. Springer, Cham.


Tissue Architecture in Cancer Initiation and Progression
Leggett, SE, Nelson, CM (2022). Tissue Architecture in Cancer Initiation and Progression. In: Akslen, L.A., Watnick, R.S. (eds) Biomarkers of the Tumor Microenvironment. Springer, Cham.


The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems
Leggett SE, Hruska AM, Guo M, Wong IY. Cell Commun Signal. 2021;19(1):32.


Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.
Leggett SE, Patel M, Valentin TM, Gamboa L, Khoo AS, Williams EK, Franck C, Wong IY. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5655-5663. 



Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development
So, E. Y., Sun, C., Wu, K. Q., Driesman, A., Leggett, S., Isaac, M., Spangler, T., Dubielecka-Szczerba, P. M., Reginato, A. M., & Liang, O. D. (2020). Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development. Journal of cellular physiology, 235(2), 1425–1437.


Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels
Khoo AS, Valentin TM, Leggett SE, et al. Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk-Collagen Hydrogels. ACS Biomater Sci Eng. 2019;5(9):4341-4354. doi:10.1021/acsbiomaterials.9b00519


Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields
Patel M, Leggett SE, Landauer AK, Wong IY, Franck C. Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields. Sci Rep. 2018 Apr 3;8(1):5581.


Multicellular Tumor Invasion and Plasticity in Biomimetic Materials
Leggett SE, Khoo AS, Wong IY. Multicellular tumor invasion and plasticity in biomimetic materials. Biomater Sci. 2017 Jul 25;5(8):1460-1479.



Stereolithographic Printing of Ionically-Crosslinked Alginate Hydrogels for Degradable Biomaterials and Microfluidics
Valentin TM, Leggett SE, Chen PY, et al. Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics. Lab Chip. 2017;17(20):3474-3488. doi:10.1039/c7lc00694b



Wrinkled, wavelength-tunable graphene-based surface topographies for directing cell alignment and morphology.
Z Wang,# D Tonderys,# SE Leggett,# Williams EK, Kiani MT, Steinberg RS, Qiu Y, Wong IY, Hurt RH. Carbon N Y. 2016 Feb 1;97:14-24. #These authors contributed equally.


Clustering and jamming in epithelial-mesenchymal co-cultures.
Gamboa Castro M, Leggett SE, Wong IY. Soft Matter. 2016 Oct 12;12(40):8327-8337.


Induction of a Mesenchymal Expression Program in Lung Epithelial Cells by Wingless Protein (Wnt)/β-Catenin Requires the Presence of c-Jun N-Terminal Kinase–1 (JNK1).
van der Velden JL, Guala AS, Leggett SE, Sluimer J, Badura EC, Janssen-Heininger YM. Am J Respir Cell Mol Biol. 2012 Sep;47(3):306-14.


Mailing address: 1406 W. Green Street, MC 278, Urbana, IL 61801 | Phone: 217.333.6350 | Office location: 2240 Everitt Laboratory | Lab location: 3202 Everitt Laboratory | e-mail: sleggett@illinois.edu